Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci
نویسندگان
چکیده
منابع مشابه
Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.
Progenitor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors. Despite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner. We studied pre-pro-B cells and Rag(-/-) progenitor-B cells to determine whether Ig locus contraction or nuclear positioning is decisive for stepwise rearrangements. We found that both Ig loc...
متن کاملImmunoglobulin β Signaling Regulates Locus Accessibility for Ordered Immunoglobulin Gene Rearrangements
The antigen receptor gene rearrangement at a given locus is tightly regulated with respect to cell lineage and developmental stage by an ill-defined mechanism. To study the possible role of precursor B cell antigen receptor (pre-BCR) signaling in the regulation of the ordered immunoglobulin (Ig) gene rearrangement during B cell differentiation, a newly developed system using mu heavy (H) chain ...
متن کاملDeprenyl Can Mediate Neuronal Protection Rather than Neuronal Rescue
Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl on m...
متن کاملLeukemogenic rearrangements at the mixed lineage leukemia gene (MLL)—multiple rather than a single mechanism
Despite manifold efforts to achieve reduced-intensity and -toxicity regimens, secondary leukemia has remained the most severe side effect of chemotherapeutic cancer treatment. Rearrangements involving a short telomeric <1 kb region of the mixed lineage leukemia (MLL) gene are the most frequently observed molecular changes in secondary as well as infant acute leukemia. Due to the mode-of-action ...
متن کاملPerihemorheology rather than parahemorheology.
However, the use of the term parahemorheology has been criticized, because the prefix para implies that the rheology of fluids and structures in the perivascular spaces is secondary and less important than that of the vessel-blood organ. It is also imprecise, once it does not refer to the fluids and structures being considered. By contrast, the term perihemorheology implies the rheology of flui...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkv928